Article
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
Journal of medical genetics - 1 Jun 2021
Di Giovannantonio Matteo, Harris Benjamin Hl, Zhang Ping, Kitchen-Smith Isaac, Xiong Lingyun, Sahgal Natasha, Stracquadanio Giovanni, Wallace Marsha, Blagden Sarah, Lord Simon, Harris David, Harris Adrian H L, Buffa Francesca M, Bond Gareth L
Abstract excerpt
BACKGROUND: Height and other anthropometric measures are consistently found to associate with differential cancer risk. However, both genetic and mechanistic insights into these epidemiological associations are notably lacking. Conversely, inherited genetic variants in tumour suppressors and oncogenes increase cancer risk, but little is known about their influence on anthropometric traits. METHODS: By integrating...
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