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Mutations in the MepRAB efflux system contribute to the in vitro development of tigecycline resistance in Staphylococcus aureus.

Journal of global antimicrobial resistance - 1 Sept 2020

Fang Renchi, Sun Yao, Dai Weisi, Zheng Xiangkuo, Tian Xuebin, Zhang Xiucai, Wang Chong, Cao Jianming, Zhou Tieli

Abstract excerpt

OBJECTIVE: To characterize the evolutionary pathways of tigecycline (TGC) resistance and alterations in the biological characteristics of hospital-derived Staphylococcus aureus isolates under selective pressure. METHODS: Three clinical S. aureus strains and one standard S. aureus strain, ATCC 29213, were used for the in vitro selection of TGC-resistant S. aureus variants with gradient concentrations of TGC....

Topics

Bacterial Proteins
Methicillin-Resistant Staphylococcus aureus
Mutation
Staphylococcus aureus
Tigecycline

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32590185
DOI: 10.1016/j.jgar.2020.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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