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Genetic changes associated with tigecycline resistance in Staphylococcus aureus in vitro-selected mutants belonging to different lineages.

International journal of antimicrobial agents - 1 Apr 2021

Herrera Melina, Gregorio Sabrina Di, Haim María Sol, Posse Graciela, Mollerach Marta, Di Conza José

Abstract excerpt

Tigecycline (TGC) resistance remains rare in Staphylococcus aureus worldwide. In this study, 12 TGC-resistant S. aureus mutants (TRSAm) were obtained displaying an increase in efflux activity. The isolates belonged to seven different genetic lineages, with a predominance of clonal complex 5 (CC5). Diverse genetic changes in mepA and mepR genes were found producing alterations in the amino acid sequences of the...

Topics

Amino Acid Sequence
Anti-Bacterial Agents
DNA, Bacterial
Drug Resistance, Bacterial
Genome, Bacterial
Humans
Membrane Transport Proteins
Microbial Sensitivity Tests
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Staphylococcal Infections

Staphylococcus aureus

Tigecycline

Source

Identifiers

PMID: 33588015
DOI: 10.1016/j.ijantimicag.2021.106304

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