Article
Eravacycline susceptibility was impacted by genetic mutation of 30S ribosome subunits, and branched-chain amino acid transport system II carrier protein, Na/Pi cotransporter family protein in Staphylococcus aureus.
BMC microbiology - 1 Jul 2020
Wang Zhanwen, Lin Zhiwei, Bai Bing, Xu Guangjian, Li Peiyu, Yu Zhijian, Deng Qiwen, Shang Yongpeng, Zheng Jinxin
Abstract excerpt
BACKGROUND: Our previous research indicated the excellent in vitro antibacterial activity of Eravacycline (Erava) and its heteroresistance frequency against clinical Staphylococcus aureus isolates. In this study, we further aimed to investigate the mechanisms of Erava resistance and heteroresistance in S. aureus. Eight parental S. aureus isolates were induced under Erava pressure in vitro and the Erava-resistant...
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