Article
Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jun 2018
Dabul Andrei Nicoli Gebieluca, Avaca-Crusca Juliana Sposto, Van Tyne Daria, Gilmore Michael S, Camargo Ilana Lopes Baratella Cunha
Abstract excerpt
A tigecycline-susceptible (TGC-S) Sequence Type (ST) 5 clinical methicillin-resistant Staphylococcus aureus (MRSA) strain was cultured in escalating levels of tigecycline, yielding mutants eightfold more resistant. Their genomes were sequenced to identify genetic alterations, resulting in resistance. Alterations in rpsJ, commonly related to tigecycline resistance, were also investigated. Tigecycline resistance...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Genome, Bacterial
- Methicillin-Resistant Staphylococcus aureus
- Microbial Sensitivity Tests
- Minocycline
- Mutation
- Staphylococcal Infections
- Tigecycline