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Article

A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.

Antimicrobial agents and chemotherapy - 1 May 2005

McAleese Fionnuala, Petersen Peter, Ruzin Alexey, Dunman Paul M, Murphy Ellen, Projan Steven J, Bradford Patricia A

Abstract excerpt

Tigecycline, an expanded-broad-spectrum glycylcycline antibiotic is not affected by the classical tetracycline resistance determinants found in Staphylococcus aureus. The in vitro selection of mutants with reduced susceptibility to tigecycline was evaluated for two methicillin-resistant S. aureus...

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Identifiers

PMID: 15855508
DOI: 10.1128/AAC.49.5.1865-1871.2005
PMCID: PMC1087644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15855508-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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