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The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation

5 May 2016

Abstract excerpt

Viruses encode secreted and cell-surface expressed proteins essential to modulate host immune defenses and establish productive infections. However, to date there has been no systematic study of the extracellular interactome of any human virus. Here we utilize the E3 proteins, diverse and rapidly evolving transmembrane-containing proteins encoded by human adenoviruses, as a model system to survey the...

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PMID: 27145901
DOI: 10.1038/ncomms11473

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