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Article

Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging.

ACS chemical biology - 17 Jul 2020

Iacovino Luca Giacinto, Manzella Nicola, Resta Jessica, Vanoni Maria Antonietta, Rotilio Laura, Pisani Leonardo, Edmondson Dale Edward, Parini Angelo, Mattevi Andrea, Mialet-Perez Jeanne, Binda Claudia

Abstract excerpt

Cardiac senescence is a typical chronic frailty condition in the elderly population, and cellular aging is often associated with oxidative stress. The mitochondrial-membrane flavoenzyme monoamine oxidase A (MAO A) catalyzes the oxidative deamination of neurotransmitters, and its expression increases in aged hearts. We produced recombinant human MAO A variants at Lys305 that play a key role in O2 reactivity...

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Identifiers

PMID: 32589395
DOI: 10.1021/acschembio.0c00366
PMCID: PMC8009472

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