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Article

Robust detection of oncometabolic aberrations by 1H-13C heteronuclear single quantum correlation in intact biological specimens.

Communications biology - 25 Jun 2020

Barekatain Yasaman, Yan Victoria C, Arthur Kenisha, Ackroyd Jeffrey J, Khadka Sunada, De Groot John, Huse Jason T, Muller Florian L

Abstract excerpt

Magnetic resonance (MR) spectroscopy has potential to non-invasively detect metabolites of diagnostic significance for precision oncology. Yet, many metabolites have similar chemical shifts, yielding highly convoluted 1H spectra of intact biological material and limiting diagnostic utility. Here, we show that hydrogen-carbon heteronuclear single quantum correlation (1H-13C HSQC) offers dramatic improvements in...

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Identifiers

PMID: 32587392
DOI: 10.1038/s42003-020-1055-5
PMCID: PMC7316726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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