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Structure-based design of an antibacterial peptide from the Myotoxin II sequence, evaluating its effectiveness against Gram-negative bacteria and its safety

8 Jul 2025

Abstract excerpt

Bacterial resistance poses a significant public health challenge, particularly for pathogens prioritized by the World Health Organization, such as carbapenem-resistant Escherichia coli . There has been growing interest in exploring animal toxins as potential alternatives to antibiotics. This study centers on the rational design of an antibiotic peptide based on the sequence 115–129 from Myotoxin II, sourced from...

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PMID: 40624141
DOI: 10.1038/s41598-025-08397-1

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