Article
Bone marrow stromal cells as replacement cells for Parkinson's disease: generation of an anatomical but not functional neuronal phenotype.
Translational research : the journal of laboratory and clinical medicine - 1 Feb 2011
Thomas Meghan G, Stone Leah, Evill Lauren, Ong Syerna, Ziman Mel, Hool Livia
Abstract excerpt
The focus of cell replacement therapies (CRTs) for Parkinson's disease has been on delivering dopamine-producing cells to the striatum. Fetal grafts have proven the feasibility of this approach, but an appropriate source of replacement cells has restricted the clinical translation. Bone marrow stromal cells (BMSCs) have been heralded as an ideal source of dopaminergic (DAergic) replacement cells, as they are...
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