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Article

Melanoma of unknown primary shows an oncogenic pattern and clinical course of sun-exposed melanoma.

The British journal of dermatology - 17 Apr 2026

Lodde Georg, Dollani Jonida, Galetzka Wolfgang, Mohr Peter, Meier Friedegund, Gutzmer Ralf, Weichenthal Michael, Utikal Jochen, Herbst Rudolf, Leiter Ulrike, Pföhler Claudia, Schilling Bastian, Terheyden Patrick, Berking Carola, Sucker Antje, Stang Andreas, Rambow Florian, Tilkorn Daniel, Roesch Alexander, Zaremba Anne, Zimmer Lisa, Tasdogan Alpaslan, Schadendorf Dirk, Ugurel Selma, Griewank Klaus, Livingstone Elisabeth

Abstract excerpt

BACKGROUND: Melanoma of unknown primary (MUP) accounts for up to 10% of all cases of metastatic melanoma. The origin of MUP is unclear, and previous studies on the clinical course in comparison with cutaneous melanoma have reported varying results. OBJECTIVES: The study was conducted to assess the oncogenic pattern of MUP and to compare the clinical course with that of melanoma of known cutaneous primary (MKP)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41719057
DOI: 10.1093/bjd/ljaf499

Genes

BRAF
KIT
NRAS
RAC1
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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