An Integrated Genomic and Transcriptomic Analysis Reveals Candidates of Susceptibility Genes for Crohn's Disease in Japanese Populations.

doi:10.1038/s41598-020-66951-5

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Article

An Integrated Genomic and Transcriptomic Analysis Reveals Candidates of Susceptibility Genes for Crohn's Disease in Japanese Populations.

Scientific reports - 24 Jun 2020

Kakuta Yoichi, Ichikawa Ryo, Fuyuno Yuta, Hirano Atsushi, Umeno Junji, Torisu Takehiro, Watanabe Kazuhiro, Asakura Akihiro, Nakano Takeru, Izumiyama Yasuhiro, Okamoto Daisuke, Naito Takeo, Moroi Rintaro, Kuroha Masatake, Kanazawa Yoshitake, Kimura Tomoya, Shiga Hisashi, Naito Takeshi, Esaki Motohiro, Kawai Yosuke, Tokunaga Katsushi, Nakamura Minoru, Matsumoto Takayuki, Nagasaki Masao, Kinouchi Yoshitaka, Unno Michiaki, Masamune Atsushi

Abstract excerpt

Expression quantitative trait locus (eQTL) analyses have enabled us to predict the function of disease susceptibility SNPs. However, eQTL for the effector memory T cells (TEM) located in the lamina propria mononuclear cells (LPMCs), which play an important role in Crohn's disease (CD), are not yet available. Thus, we conducted RNA sequencing and eQTL analyses of TEM cells located in the LPMCs from IBD patients...

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PMID: 32581322
DOI: 10.1038/s41598-020-66951-5
PMCID: PMC7314801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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