Article
Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease.
PloS one - 1 Jan 2018
Chiba Hirofumi, Kakuta Yoichi, Kinouchi Yoshitaka, Kawai Yosuke, Watanabe Kazuhiro, Nagao Munenori, Naito Takeo, Onodera Motoyuki, Moroi Rintaro, Kuroha Masatake, Kanazawa Yoshitake, Kimura Tomoya, Shiga Hisashi, Endo Katsuya, Negoro Kenichi, Nagasaki Masao, Unno Michiaki, Shimosegawa Tooru
Abstract excerpt
BACKGROUND: Inflammatory bowel disease (IBD) has an unknown etiology; however, accumulating evidence suggests that IBD is a multifactorial disease influenced by a combination of genetic and environmental factors. The influence of genetic variants on DNA methylation in cis and cis effects on expression have been demonstrated. We hypothesized that IBD susceptibility single-nucleotide polymorphisms (SNPs) regulate...
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