Article

Single-atom inhibition of oncogenic drivers through cysteine coordination

2026-08-28

Abstract excerpt

Small-molecule inhibitors rely on molecular recognition within suitable binding pockets, leaving many disease-associated proteins difficult to target. Here, we introduce the concept of a single-atom inhibitor in which gold (Au) engages critical cysteine residues of oncogenic drivers to suppress their activity. We used an AI-assisted few-shot learning approach to identify EGFR-targeting peptides for in vivo Au deli...

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Literature Corpus work: 6acfbf59-46f3-57b0-832c-c9d4521b64b1
DOI: 10.64898/2026.08.27.747489

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