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Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice

24 Jun 2020

Abstract excerpt

The microbiota has been linked to the development of atherosclerosis, but the functional impact of these resident bacteria on the lesion size and cellular composition of atherosclerotic plaques in the aorta has never been experimentally addressed with the germ-free low-density lipoprotein receptor-deficient (Ldlr−/-) mouse atherosclerosis model. Here, we report that 16 weeks of high-fat diet (HFD) feeding of...

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PMID: 32579470
DOI: 10.1080/19490976.2020.1767463

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