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Article

A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2020

Jones Hannah J, Martin David, Lewis Sarah J, Davey Smith George, O'Donovan Michael C, Owen Michael J, Walters James T R, Zammit Stanley

Abstract excerpt

Schizophrenia shows a genetic correlation with both anxiety disorder and neuroticism, a trait strongly associated with anxiety. However, genetic correlations do not discern causality from genetic confounding. We therefore aimed to investigate whether anxiety-related phenotypes lie on the causal pathway to schizophrenia using Mendelian randomization (MR). Four MR methods, each with different assumptions regarding...

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Identifiers

PMID: 32578352
DOI: 10.1002/ajmg.b.32808

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