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Causal links between personality disorders and schizophrenia: A Mendelian randomization study.

Medicine - 16 May 2025

Cheng Gangming, Xu Lin, Li Hongjie, Cheng Yuan, Jiang Tao, Xu Qiong, Wang Jing

Abstract excerpt

Although observational studies have suggested associations between personality disorders and schizophrenia, the causality of these relationships remains unclear. Determining whether personality disorders causally contribute to schizophrenia could inform early identification and preventive efforts. We performed two-sample Mendelian randomization (MR) analysis using large-scale Genome-wide Association Study data...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Personality Disorders
Polymorphism, Single Nucleotide

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PMID: 40388757
DOI: 10.1097/MD.0000000000042532
PMCID: PMC12091683

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