Article
Genome-wide DNA methylation analysis of KRAS mutant cell lines.
Scientific reports - 23 Jun 2020
Tew Ben Yi, Durand Joel K, Bryant Kirsten L, Hayes Tikvah K, Peng Sen, Tran Nhan L, Gooden Gerald C, Buckley David N, Der Channing J, Baldwin Albert S, Salhia Bodour
Abstract excerpt
Oncogenic RAS mutations are associated with DNA methylation changes that alter gene expression to drive cancer. Recent studies suggest that DNA methylation changes may be stochastic in nature, while other groups propose distinct signaling pathways responsible for aberrant methylation. Better understanding of DNA methylation events associated with oncogenic KRAS expression could enhance therapeutic approaches....
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