Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers.

doi:10.1126/science.adk0775

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Article

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers.

Science (New York, N.Y.) - 7 Jun 2024

Klomp Jeffrey A, Klomp Jennifer E, Stalnecker Clint A, Bryant Kirsten L, Edwards A Cole, Drizyte-Miller Kristina, Hibshman Priya S, Diehl J Nathaniel, Lee Ye S, Morales Alexis J, Taylor Khalilah E, Peng Sen, Tran Nhan L, Herring Laura E, Prevatte Alex W, Barker Natalie K, Hover Laura D, Hallin Jill, Sorokin Alexey, Kanikarla Preeti Marie, Chowdhury Saikat, Coker Oluwadara, Lee Hey Min, Goodwin Craig M, Gautam Prson, Olson Peter, Christensen James G, Shen John P, Kopetz Scott, Graves Lee M, Lim Kian-Huat, Wang-Gillam Andrea, Wennerberg Krister, Cox Adrienne D, Der Channing J

Abstract excerpt

How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we established a systemwide portrait of KRAS- and extracellular signal-regulated kinase (ERK)-dependent gene transcription in KRAS-mutant cancer to delineate the molecular mechanisms of growth and of inhibitor resistance. Unexpectedly, our KRAS-dependent gene signature diverges substantially from the frequently cited Hallmark KRAS...

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Identifiers

PMID: 38843331
DOI: 10.1126/science.adk0775
PMCID: PMC11301402

Genes

KRAS
APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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