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BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells

9 Jan 2015

Abstract excerpt

Triple-negative breast cancer (TNBC) has poor prognostic outcome compared with other types of breast cancer. The molecular and cellular mechanisms underlying TNBC pathology are not fully understood. Here, we report that the transcription factor BCL11A is overexpressed in TNBC including basal-like breast cancer (BLBC) and that its genomic locus is amplified in up to 38% of BLBC tumours. Exogenous BCL11A...

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PMID: 25574598
DOI: 10.1038/ncomms6987

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