Article
Liver damage and sickle cell disease: genotype relationship.
Annals of hematology - 1 Sept 2020
Bortolotti Marta, D'Ambrosio Roberta, Fraquelli Mirella, Pedrotti Patrizia, Consonni Dario, Migone De Amicis Margherita, Scaramellini Natalia, Di Pierro Elena, Graziadei Giovanna
Abstract excerpt
Sickle hepatopathy is a severe and not rare complication of sickle cell disease (SCD), showing mainly a cholestatic pattern. So far, no effective approaches to prevent or treat this condition have been recognized. We conducted a single-center observational study in 68 adult sickle cell patients, encompassing 17 with sickle cell anemia (SCA), 38 with sickle cell thalassemia (HbS/β-Thal), and 13 with HbSC disease....
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