Article
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.
Science (New York, N.Y.) - 7 Aug 2020
Chi Xiangyang, Yan Renhong, Zhang Jun, Zhang Guanying, Zhang Yuanyuan, Hao Meng, Zhang Zhe, Fan Pengfei, Dong Yunzhu, Yang Yilong, Chen Zhengshan, Guo Yingying, Zhang Jinlong, Li Yaning, Song Xiaohong, Chen Yi, Xia Lu, Fu Ling, Hou Lihua, Xu Junjie, Yu Changming, Li Jianmin, Zhou Qiang, Chen Wei
Abstract excerpt
Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be guided by the distribution of epitopes, not only on the receptor binding domain (RBD) of the Spike (S) protein but also across the full Spike (S) protein. We isolated and characterized monoclonal antibodies (mAbs) from 10 convalescent COVID-19 patients. Three mAbs showed neutralizing activities against authentic...
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