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Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD

1 Oct 2021

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has necessitated the rapid development of antibody-based therapies and vaccines as countermeasures. Here, we use cryoelectron microscopy (cryo-EM) to characterize two protective anti-SARS-CoV-2 murine monoclonal antibodies (mAbs) in complex with the spike protein, revealing similarities between epitopes targeted by human and murine B cells....

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PMID: 34655519
DOI: 10.1016/j.celrep.2021.109881

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