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Article

Induced pluripotent stem cells provide mega insights into kidney disease.

Kidney international - 1 Jul 2020

Luciani Alessandro, Freedman Benjamin S

Abstract excerpt

Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal system into the spotlight, as it is proposed to play a central role in the regulation of megalin in...

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Identifiers

PMID: 32571490
DOI: 10.1016/j.kint.2020.04.033
PMCID: PMC8204406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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