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Challenges in T cell receptor gene therapy

20 May 2012

Abstract excerpt

The function of T lymphocytes as orchestrators and effectors of the adaptive immune response is directed by the specificity of their T cell receptors (TCRs). By transferring into T cells the genes encoding antigen-specific receptors, the functional activity of large populations of T cells can be redirected against defined targets including virally infected or cancer cells. The potential of therapeutic T cells to...

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PMID: 22610778
DOI: 10.1002/jgm.2637

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