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Article

Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability.

DNA repair - 1 Jan 2021

Jia Qian, Zeng Hui, Tu Jie, Sun Litao, Cao Weiguo, Xie Wei

Abstract excerpt

UdgX from Mycobacterium smegmatis (MsmUdgX) is a prototypical enzyme representing a new class of uracil-DNA glycosylases (UDG) closely related to the family 4 enzymes. It possesses a unique R-loop rich in positive residues and forms a covalent bond with single-stranded uracil-containing DNAs (ssDNA-Us) that is resistant to denaturants after the removal of the target uracil. We previously identified the H109E...

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PMID: 33248387
DOI: 10.1016/j.dnarep.2020.103008

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