Article
A unique uracil-DNA binding protein of the uracil DNA glycosylase superfamily.
Nucleic acids research - 30 Sept 2015
Sang Pau Biak, Srinath Thiruneelakantan, Patil Aravind Goud, Woo Eui-Jeon, Varshney Umesh
Abstract excerpt
Uracil DNA glycosylases (UDGs) are an important group of DNA repair enzymes, which pioneer the base excision repair pathway by recognizing and excising uracil from DNA. Based on two short conserved sequences (motifs A and B), UDGs have been classified into six families. Here we report a novel UDG, UdgX, from Mycobacterium smegmatis and other organisms. UdgX specifically recognizes uracil in DNA, forms a tight...
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