Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Triptolide attenuates laser-induced choroidal neovascularization via M2 macrophage in a mouse model.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Sept 2020

Lai Kunbei, Gong Yajun, Zhao Wenbo, Li Longhui, Huang Chuangxin, Xu Fabao, Zhong Xiaojing, Jin Chenjin

Abstract excerpt

PURPOSE: To investigate whether triptolide has inhibitory effects on the development of choroidal neovascularization (CNV), together with its underlying anti-angiogenic mechanisms. METHODS: CNV was induced in C57BL/6 J mice using laser photocoagulation. Triptolide at concentrations of 0.035 and 0.07 mg/kg body weight (BW) or the same volume of phosphate-buffered saline (PBS) was intraperitoneally injected into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis Inhibitors
Share to Choroid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Choroidal Neovascularization

Share to Diterpenes

Share to Epoxy Compounds

Share to Human Umbilical Vein Endothelial Cells

Share to Intercellular Adhesion Molecule-1

Share to Phenanthrenes

Source

Identifiers

PMID: 32559620
DOI: 10.1016/j.biopha.2020.110312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Triptolide attenuates laser-induced choroidal neovascularization via M2 macrophage in a mouse model.PMID 32559620Read ↗

The dynamic changes of macrophage morphology in progression of choroidal neovascularization in laser-induced choroidal neovascularization mice modelSemantic proximity Read ↗

Intravitreal TSG-6 suppresses laser-induced choroidal neovascularization by inhibiting CCR2+ monocyte recruitmentSemantic proximity Read ↗

Different distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularizationSemantic proximity Read ↗

MicroRNA-155 Inhibits Polarization of Macrophages to M2-Type and Suppresses Choroidal Neovascularization.Semantic proximity Read ↗

PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD modelsSemantic proximity Read ↗

Interleukin-17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization.Semantic proximity Read ↗

Macrophages Inhibit Neovascularization in a Murine Model of Age-Related Macular DegenerationSemantic proximity Read ↗

TAK1 blockade as a therapy for retinal neovascularizationSemantic proximity Read ↗

VEGF-production by CCR2-dependent macrophages contributes to laser-induced choroidal neovascularization.Semantic proximity Read ↗

A Triple-Action Nanoplatform for Retinal Neovascularization: Penetrating Ocular Barriers, Blocking Angiogenesis and Fibrosis, and Restoring MitophagySemantic proximity Read ↗

Triptolide attenuates oxidative stress, NF-κB activation and multiple cytokine gene expression in murine peritoneal macrophageSemantic proximity Read ↗

Topical Administration of the Kappa Opioid Receptor Agonist Nalfurafine Suppresses Corneal Neovascularization and InflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.