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Article

Interleukin-17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization.

Immunology - 1 Apr 2016

Zhu Yanji, Tan Wei, Demetriades Anna M, Cai Yujuan, Gao Yushuo, Sui Ailing, Lu Qing, Shen Xi, Jiang Chunhui, Xie Bing, Sun Xinghuai

Abstract excerpt

Neovascularization (NV), as a cardinal complication of several ocular diseases, has been intensively studied, and research has shown its close association with inflammation and immune cells. In the present study, the role of interleukin-17A (IL-17A) in angiogenesis in the process of ocular NV both in vivo and in vitro was investigated. Also, a paracrine role of IL-17A was demonstrated in the crosstalk between...

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Source

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Identifiers

PMID: 26694999
DOI: 10.1111/imm.12571
PMCID: PMC4799882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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