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Article

PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models

13 Oct 2022

Abstract excerpt

Abstract Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to the pathogenesis of choroidal neovascularization (CNV) in exudative AMD (wet AMD). This study describes the effects of cyclooxygenase-2 (COX2)/prostaglandin E 2 (PGE 2 ) signalling on the...

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PMID: 36229856
DOI: 10.1186/s12964-022-00973-6

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