Article
MicroRNA-155 Inhibits Polarization of Macrophages to M2-Type and Suppresses Choroidal Neovascularization.
Inflammation - 1 Feb 2018
Zhang Pengfei, Wang Hong, Luo Xueting, Liu Haiyun, Lu Bing, Li Tong, Yang Shiqi, Gu Qing, Li Bin, Wang Fenghua, Sun Xiaodong
Abstract excerpt
Arg-1+Ym-1+ M2-type macrophages play essential roles in the development of choroidal neovascularization (CNV). Thus, inhibition of M2-type macrophages may be effective in suppressing CNV. However, the potential mechanisms of macrophage polarization during development of CNV remain unclear. In this study, we report that microRNA-155 (miR-155) inhibited M2 polarization by targeting C/EBPβ in CNV model mice and in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.