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Article

VEGF-production by CCR2-dependent macrophages contributes to laser-induced choroidal neovascularization.

PloS one - 1 Jan 2014

Krause Torsten A, Alex Anne F, Engel Daniel R, Kurts Christian, Eter Nicole

Abstract excerpt

Age-related macular degeneration (AMD) is the most prevalent cause of blindness in the elderly, and its exsudative subtype critically depends on local production of vascular endothelial growth factor A (VEGF). Mononuclear phagocytes, such as macrophages and microglia cells, can produce VEGF. Their precursors, for example monocytes, can be recruited to sites of inflammation by the chemokine receptor CCR2, and this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24714223
DOI: 10.1371/journal.pone.0094313
PMCID: PMC3979804

Genes

CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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