Article

Topical Administration of the Kappa Opioid Receptor Agonist Nalfurafine Suppresses Corneal Neovascularization and Inflammation

2020-12-10

Abstract excerpt

Corneal neovascularization (CNV) causes higher-order aberrations, corneal edema, ocular inflammation, and corneal transplant rejection, thereby decreasing visual acuity. Here, we investigated the effects of topical administration of the kappa opioid receptor agonist nalfurafine (TRK-820) on CNV. To induce CNV, intrastromal corneal sutures were placed on the corneal stroma of BALB/c mice for 2 weeks. Nalfurafine (0...

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Literature Corpus work: 7bc937d8-c2f3-5ab5-9a2c-2306eae3bd5d
DOI: 10.21203/rs.3.rs-122445/v1

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