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Photodegradable Hydrogels for Rapid Screening, Isolation, and Genetic Characterization of Bacteria with Rare Phenotypes.

Biomacromolecules - 10 Aug 2020

Fattahi Niloufar, Nieves-Otero Priscila A, Masigol Mohammadali, van der Vlies André J, Jensen Reilly S, Hansen Ryan R, Platt Thomas G

Abstract excerpt

Screening mutant libraries (MLs) of bacteria for strains with specific phenotypes is often a slow and laborious process that requires assessment of tens of thousands of individual cell colonies after plating and culturing on solid media. In this report, we develop a three-dimensional, photodegradable hydrogel interface designed to dramatically improve the throughput of ML screening by combining high-density cell...

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Identifiers

PMID: 32559368
DOI: 10.1021/acs.biomac.0c00543
PMCID: PMC8906371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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