Article
Factors promoting nuclear envelope assembly independent of the canonical ESCRT pathway.
The Journal of cell biology - 1 Jun 2020
Lee I-Ju, Stokasimov Ema, Dempsey Nathaniel, Varberg Joseph M, Jacob Etai, Jaspersen Sue L, Pellman David
Abstract excerpt
The nuclear envelope (NE) undergoes dynamic remodeling to maintain NE integrity, a process involving the inner nuclear membrane protein LEM2 recruiting CHMP7/Cmp7 and then ESCRT-III. However, prior work has hinted at CHMP7/ESCRT-independent mechanisms. To identify such mechanisms, we studied NE assembly in Schizosaccharomyces japonicus, a fission yeast that undergoes partial mitotic NE breakdown and reassembly....
Topics
- DNA-Binding Proteins
- Endosomal Sorting Complexes Required for Transport
- Membrane Proteins
- Microscopy, Electron, Scanning
- Mitosis
- Mutation
- Nuclear Envelope
- Nuclear Proteins
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Stearoyl-CoA Desaturase
- Up-Regulation