Article
Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves.
PLoS genetics - 1 Jun 2020
Takamiya Masanari, Stegmaier Johannes, Kobitski Andrei Yu, Schott Benjamin, Weger Benjamin D, Margariti Dimitra, Cereceda Delgado Angel R, Gourain Victor, Scherr Tim, Yang Lixin, Sorge Sebastian, Otte Jens C, Hartmann Volker, van Wezel Jos, Stotzka Rainer, Reinhard Thomas, Schlunck Günther, Dickmeis Thomas, Rastegar Sepand, Mikut Ralf, Nienhaus Gerd Ulrich, Strähle Uwe
Abstract excerpt
Cranial neural crest (NC) contributes to the developing vertebrate eye. By multidimensional, quantitative imaging, we traced the origin of the ocular NC cells to two distinct NC populations that differ in the maintenance of sox10 expression, Wnt signalling, origin, route, mode and destination of migration. The first NC population migrates to the proximal and the second NC cell group populates the distal...
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