Article
Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber.
PloS one - 1 Jan 2015
Takamiya Masanari, Weger Benjamin D, Schindler Simone, Beil Tanja, Yang Lixin, Armant Olivier, Ferg Marco, Schlunck Günther, Reinhard Thomas, Dickmeis Thomas, Rastegar Sepand, Strähle Uwe
Abstract excerpt
The cornea is a central component of the camera eye of vertebrates and even slight corneal disturbances severely affect vision. The transcription factor PAX6 is required for normal eye development, namely the proper separation of the lens from the developing cornea and the formation of the iris and anterior chamber. Human PAX6 mutations are associated with severe ocular disorders such as aniridia, Peters anomaly...
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