Article
Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.
Acta neuropathologica communications - 10 Jun 2014
Niedowicz Dana M, Reeves Valerie L, Platt Thomas L, Kohler Katharina, Beckett Tina L, Powell David K, Lee Tiffany L, Sexton Travis R, Song Eun Suk, Brewer Lawrence D, Latimer Caitlin S, Kraner Susan D, Larson Kara L, Ozcan Sabire, Norris Christopher M, Hersh Louis B, Porter Nada M, Wilcock Donna M, Murphy Michael Paul
Abstract excerpt
Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for Alzheimer's disease (AD), though the underlying mechanisms are unknown. We have created a novel mouse model that recapitulates features of T2DM and AD by crossing morbidly obese and diabetic db/db mice with APPΔNL/ΔNLx PS1P264L/P264L knock-in mice. These mice (db/AD) retain many features of the parental lines (e.g. extreme...
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