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Article

PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome.

Scientific reports - 17 Jun 2020

Sun Jiandong, Liu Yan, Zhu Guoqi, Cato Caleb, Hao Xiaoning, Qian Li, Lin Weiju, Adhikari Rachana, Luo Yun, Baudry Michel, Bi Xiaoning

Abstract excerpt

The ubiquitin ligase, Ube3a, plays important roles in brain development and functions, since its deficiency results in Angelman Syndrome (AS) while its over-expression increases the risk for autism. We previously showed that the lack of Ube3a-mediated ubiquitination of the Ca2+-activated small conductance potassium channel, SK2, contributes to impairment of synaptic plasticity and learning in AS mice. Synaptic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32555345
DOI: 10.1038/s41598-020-66790-4
PMCID: PMC7299966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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