Article
Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis.
Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2011
Konopacki Filip A, Jaafari Nadia, Rocca Dan L, Wilkinson Kevin A, Chamberlain Sophie, Rubin Philip, Kantamneni Sriharsha, Mellor Jack R, Henley Jeremy M
Abstract excerpt
The surface expression and regulated endocytosis of kainate (KA) receptors (KARs) plays a critical role in neuronal function. PKC can modulate KAR trafficking, but the sites of action and molecular consequences have not been fully characterized. Small ubiquitin-like modifier (SUMO) modification of the KAR subunit GluK2 mediates agonist-evoked internalization, but how KAR activation leads to GluK2 SUMOylation is...
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