Computational Pharmacogenetics of P-Glycoprotein Mediated Antiepileptic Drug Resistance

Abstract excerpt

The treatment of epilepsy using antiepileptogenic drugs is complicated by drug re-sistance, resulting in treatment failure in more than one-third of cases. Human P-glycoprotein (hPGP; MDR1 ) is a known epileptogenic mediator. Given that experimental investigations have suggested a role for pharmacogenetics in this treatment failure, it would be of interest to study hPGP polymorphisms that might contribute to the...

Topics

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• Anticonvulsants
• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Drug Interactions
• Drug Resistance
• Epilepsy
• Gene Expression Regulation
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

e0e3a213-3fe7-5153-91f3-484830c9a860

DOI

10.1101/095059