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High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile

1 Jun 2020

Abstract excerpt

Vδ2 + T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here, we demonstrate that CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2 + T cell subsets. Despite distinct antigen specificities, CD26 hi CD94 lo Vδ2 + cells exhibit substantial similarities to CD26 hi mucosal-associated invariant T (MAIT) cells,...

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PMID: 32553157
DOI: 10.1016/j.celrep.2020.107773

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