Genomic Locus Tagged by Lung Function GWAS SNV rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype.

doi:10.1096/fj.202403208R

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genomic Locus Tagged by Lung Function GWAS SNV rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 30 Jun 2025

Grech Godwin M, Fawcett Katherine A, Hall Robert J, Grech Godfrey, Ellul-Micallef Roger, Hall Ian P, Fenech Anthony G

Abstract excerpt

SNV rs12477314 (C>T; 1000G MAF = 0.14), which maps to an intergenic region on 2q37.3, is a genome-wide significant association signal for pulmonary function in genome-wide association study meta-analyses. Bioinformatic analysis revealed that the intergenic region in proximity to the sentinel SNV is enriched for histone methylation markers suggestive of active enhancer regions modifiable by DNA methylation. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Enhancer Elements, Genetic

Share to Genome-Wide Association Study

Share to Inflammation

Share to Lung

Share to Polymorphism, Single Nucleotide

Share to Pulmonary Disease, Chronic Obstructive

Source

Open in PubMed Open full text

Identifiers

PMID: 40512334
DOI: 10.1096/fj.202403208R
PMCID: PMC12164972

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Locus Tagged by Lung Function GWAS SNV rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype.PMID 40512334Read ↗

Whole Genome Sequence Analysis of Pulmonary Function and COPD in 44,287 Multi-ancestry ParticipantsSemantic proximity Read ↗

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.Semantic proximity Read ↗

Expanded genetic landscape of chronic obstructive pulmonary disease reveals heterogeneous cell type and phenotype associationsSemantic proximity Read ↗

Context-specific eQTLs reveal causal genes underlying shared genetic architecture of critically ill COVID-19 and idiopathic pulmonary fibrosisSemantic proximity Read ↗

Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease.Semantic proximity Read ↗

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung functionSemantic proximity Read ↗

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPDSemantic proximity Read ↗

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.Semantic proximity Read ↗

The Idiopathic Pulmonary Fibrosis-associated single nucleotide polymorphism rs35705950 is transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1)Semantic proximity Read ↗

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPDSemantic proximity Read ↗

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes.Semantic proximity Read ↗

An allele-specific functional SNP associated with two autoimmune diseases modulates <i>IRF5</i> expression by long-range chromatin loop formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.