Article
Targeted resequencing reveals genetic risks in patients with sporadic idiopathic pulmonary fibrosis.
Human mutation - 1 Sept 2018
Deng Yanhan, Li Zongzhe, Liu Juan, Wang Zheng, Cao Yanyan, Mou Yong, Fu Bohua, Mo Biwen, Wei Jianghong, Cheng Zhenshun, Luo Liman, Li Jingping, Shu Ying, Wang Xiaomei, Luo Guangwei, Yang Shuo, Wang Yingnan, Zhu Jing, Yang Jingping, Wu Ming, Xu Xuyan, Ge Renying, Chen Xueqin, Peng Qingzhen, Wei Guang, Li Yaqing, Yang Hua, Fang Shirong, Zhang Xiaoju, Xiong Weining
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a genetic heterogeneous disease with high mortality and poor prognosis. However, a large fraction of genetic cause remains unexplained, especially in sporadic IPF (∼80% IPF). By systemically reviewing related literature and potential pathogenic pathways, 92 potentially IPF-related genes were selected and sequenced in genomic DNAs from 253 sporadic IPF patients and 125...
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