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Article

Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness

19 Apr 2019

Abstract excerpt

Abstract Advanced and metastatic squamous cell carcinomas (SCC) are common and difficult-to-treat malignancies. We assessed 75 immunotherapy-treated patients with SCC from a clinically annotated database of 2,651 patients, as well as 9,407 patients from a deidentified database for molecular features that might influence checkpoint blockade response. SCCs had higher tumor mutational burdens (TMB) than non-SCCs (P...

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PMID: 31003990
DOI: 10.1158/2326-6066.cir-18-0716

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