Heterozygous Genotype rs17580 AT (PiS) in SERPINA1 is Associated with COPD Secondary to Biomass-Burning and Tobacco Smoking: A Case-Control and Populational Study.

doi:10.2147/COPD.S247446

Article

Heterozygous Genotype rs17580 AT (PiS) in SERPINA1 is Associated with COPD Secondary to Biomass-Burning and Tobacco Smoking: A Case-Control and Populational Study.

International journal of chronic obstructive pulmonary disease - 1 Jan 2020

Pérez-Rubio Gloria, Ambrocio-Ortiz Enrique, López-Flores Luis A, Juárez-Martín Ana I, Jiménez-Valverde Luis Octavio, Zoreque-Cabrera Susana, Galicia-Negrete Gustavo, Ramírez-Díaz María Elena, Cruz-Vicente Filiberto, Castillejos-López Manuel de Jesús, Salinas-Lara Citlaltepetl, Hernández-Zenteno Rafael de Jesús, Ramírez-Venegas Alejandra, Falfán-Valencia Ramcés

Abstract excerpt

Purpose: The protease inhibitor S (PiS) and Z (PiZ) variants have been stated as the only genetic cause of chronic obstructive pulmonary disease (COPD) in Caucasians. However, its frequency in admixed populations is low. We aimed to identify genetic susceptibility between PiS (rs17580) and PiZ (rs28929474) polymorphisms with COPD related to tobacco smoking and biomass-burning smoke as well as to determine its...

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Heterozygous Genotype rs17580 AT (PiS) in SERPINA1 is Associated with COPD Secondary to Biomass-Burning and Tobacco Smoking: A Case-Control and Populational Study.

Abstract excerpt

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