Article
The protease inhibitor PI*S allele and COPD: a meta-analysis.
The European respiratory journal - 1 Jul 2005
Dahl M, Hersh C P, Ly N P, Berkey C S, Silverman E K, Nordestgaard B G
Abstract excerpt
In many countries, the protease inhibitor (SERPINA1) PI*S allele is more common than PI*Z, the allele responsible for most cases of chronic obstructive pulmonary disease (COPD) due to severe alpha 1-antitrypsin deficiency. However, the risk of COPD due to the PI*S allele is not clear. The current authors located studies that addressed the risk of COPD or measured lung function in individuals with the PI SZ, PI MS...
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