Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimated Prevalence and Number of PiMZ Genotypes of Alpha-1 Antitrypsin in Seventy-Four Countries Worldwide.

International journal of chronic obstructive pulmonary disease - 1 Jan 2000

Martinez-González Cristina, Blanco Ignacio, Diego Isidro, Bueno Patricia, Miravitlles Marc

Abstract excerpt

BACKGROUND: The α-1 antitrypsin (AAT) protease inhibitor PiMZ is a moderately deficient genotype, until recently considered of little or negligible risk. However, a growing number of studies show that MZ carriers have an increased risk of developing lung and liver diseases, if exposed to smoking or other airborne or industrial pollutants, and hepatotoxic substances. METHODS: We used the epidemiological studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha 1-Antitrypsin
Share to alpha 1-Antitrypsin Deficiency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Phenotype

Share to Prevalence

Share to Pulmonary Disease, Chronic Obstructive

Source

Open in PubMed Open full text

Identifiers

PMID: 34556982
DOI: 10.2147/COPD.S327803
PMCID: PMC8455519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimated Prevalence and Number of PiMZ Genotypes of Alpha-1 Antitrypsin in Seventy-Four Countries Worldwide.PMID 34556982Read ↗

Genetic epidemiology of alpha-1 antitrypsin deficiency in southern Europe: France, Italy, Portugal and Spain.Semantic proximity Read ↗

Genetic epidemiology of alpha-1 antitrypsin deficiency in North America and Australia/New Zealand: Australia, Canada, New Zealand and the United States of America.Semantic proximity Read ↗

PI S and PI Z alpha-1 antitrypsin deficiency worldwide. A review of existing genetic epidemiological data.Semantic proximity Read ↗

[PI*S and PI*Z alpha 1-antitrypsin deficiency: estimated prevalence and number of deficient subjects in Spain].Semantic proximity Read ↗

Frequency of alleles and genotypes associated with alpha-1 antitrypsin deficiency in clinical and general populations: Revelations about underdiagnosis.Semantic proximity Read ↗

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype.Semantic proximity Read ↗

Prevalence of Alpha-1 Antitrypsin Deficiency (AATD) in a General Population of Northern Italy: A Descriptive AnalysisSemantic proximity Read ↗

Alpha-1 antitrypsin Pi*SZ genotype: estimated prevalence and number of SZ subjects worldwide.Semantic proximity Read ↗

Prevalence of α1-antitrypsin deficiency alleles PI*S and PI*Z worldwide and effective screening for each of the five phenotypic classes PI*MS, PI*MZ, PI*SS, PI*SZ, and PI*ZZ: a comprehensive review.Semantic proximity Read ↗

Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update.Semantic proximity Read ↗

Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles.Semantic proximity Read ↗

Alpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.