Article
Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies.
Science (New York, N.Y.) - 21 Aug 2020
Baum Alina, Fulton Benjamin O, Wloga Elzbieta, Copin Richard, Pascal Kristen E, Russo Vincenzo, Giordano Stephanie, Lanza Kathryn, Negron Nicole, Ni Min, Wei Yi, Atwal Gurinder S, Murphy Andrew J, Stahl Neil, Yancopoulos George D, Kyratsous Christos A
Abstract excerpt
Antibodies targeting the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present a promising approach to combat the coronavirus disease 2019 (COVID-19) pandemic; however, concerns remain that mutations can yield antibody resistance. We investigated the development of resistance against four antibodies to the spike protein that potently neutralize SARS-CoV-2, individually as well as...
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